HIGH-SENSITIVITY IMAGING OF MAGNETIC FIELDS FROM CARDIAC APEX ACTION POTENTIAL PROPAGATION USING SUPERCONDUCTING QUANTUM INTERFERENCE DEVICE (SQUID) MICROSCOPY

In this dissertation, we explore the magnetic fields associated with action potential propagation in the spiral fiber structure of a rabbits cardiac apex. We use optical imaging, SQUID microscopy, monodomain and bidomain modeling to analyze the spiral effect on action potential propagation. We found...

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Bibliographic Details
Main Author:	McBride, Krista Kay
Other Authors:	Michael I Miga
Format:	Others
Language:	en
Published:	VANDERBILT 2008
Subjects:	Physics
Online Access:	http://etd.library.vanderbilt.edu/available/etd-07222008-092825/

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spelling	ndltd-VANDERBILT-oai-VANDERBILTETD-etd-07222008-0928252013-01-08T17:16:21Z HIGH-SENSITIVITY IMAGING OF MAGNETIC FIELDS FROM CARDIAC APEX ACTION POTENTIAL PROPAGATION USING SUPERCONDUCTING QUANTUM INTERFERENCE DEVICE (SQUID) MICROSCOPY McBride, Krista Kay Physics In this dissertation, we explore the magnetic fields associated with action potential propagation in the spiral fiber structure of a rabbits cardiac apex. We use optical imaging, SQUID microscopy, monodomain and bidomain modeling to analyze the spiral effect on action potential propagation. We found that the spiral structure gives a distinct magnetic imprint that can be reproduced by monodomain and bidomain modeling. The SQUID microscope has also been improved by implementing a lever mechanism and monolithic SQUID sensors for higher magnetic spatial resolution and sensitivity measurements. Michael I Miga Alan Bradshaw Sait A Umar John P. Wikswo Franz J Baudenbacher VANDERBILT 2008-07-26 text application/pdf http://etd.library.vanderbilt.edu/available/etd-07222008-092825/ http://etd.library.vanderbilt.edu/available/etd-07222008-092825/ en unrestricted I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.
collection	NDLTD
language	en
format	Others
sources	NDLTD
topic	Physics
spellingShingle	Physics McBride, Krista Kay HIGH-SENSITIVITY IMAGING OF MAGNETIC FIELDS FROM CARDIAC APEX ACTION POTENTIAL PROPAGATION USING SUPERCONDUCTING QUANTUM INTERFERENCE DEVICE (SQUID) MICROSCOPY
description	In this dissertation, we explore the magnetic fields associated with action potential propagation in the spiral fiber structure of a rabbits cardiac apex. We use optical imaging, SQUID microscopy, monodomain and bidomain modeling to analyze the spiral effect on action potential propagation. We found that the spiral structure gives a distinct magnetic imprint that can be reproduced by monodomain and bidomain modeling. The SQUID microscope has also been improved by implementing a lever mechanism and monolithic SQUID sensors for higher magnetic spatial resolution and sensitivity measurements.
author2	Michael I Miga
author_facet	Michael I Miga McBride, Krista Kay
author	McBride, Krista Kay
author_sort	McBride, Krista Kay
title	HIGH-SENSITIVITY IMAGING OF MAGNETIC FIELDS FROM CARDIAC APEX ACTION POTENTIAL PROPAGATION USING SUPERCONDUCTING QUANTUM INTERFERENCE DEVICE (SQUID) MICROSCOPY
title_short	HIGH-SENSITIVITY IMAGING OF MAGNETIC FIELDS FROM CARDIAC APEX ACTION POTENTIAL PROPAGATION USING SUPERCONDUCTING QUANTUM INTERFERENCE DEVICE (SQUID) MICROSCOPY
title_full	HIGH-SENSITIVITY IMAGING OF MAGNETIC FIELDS FROM CARDIAC APEX ACTION POTENTIAL PROPAGATION USING SUPERCONDUCTING QUANTUM INTERFERENCE DEVICE (SQUID) MICROSCOPY
title_fullStr	HIGH-SENSITIVITY IMAGING OF MAGNETIC FIELDS FROM CARDIAC APEX ACTION POTENTIAL PROPAGATION USING SUPERCONDUCTING QUANTUM INTERFERENCE DEVICE (SQUID) MICROSCOPY
title_full_unstemmed	HIGH-SENSITIVITY IMAGING OF MAGNETIC FIELDS FROM CARDIAC APEX ACTION POTENTIAL PROPAGATION USING SUPERCONDUCTING QUANTUM INTERFERENCE DEVICE (SQUID) MICROSCOPY
title_sort	high-sensitivity imaging of magnetic fields from cardiac apex action potential propagation using superconducting quantum interference device (squid) microscopy
publisher	VANDERBILT
publishDate	2008
url	http://etd.library.vanderbilt.edu/available/etd-07222008-092825/
work_keys_str_mv	AT mcbridekristakay highsensitivityimagingofmagneticfieldsfromcardiacapexactionpotentialpropagationusingsuperconductingquantuminterferencedevicesquidmicroscopy
_version_	1716570355851591680

HIGH-SENSITIVITY IMAGING OF MAGNETIC FIELDS FROM CARDIAC APEX ACTION POTENTIAL PROPAGATION USING SUPERCONDUCTING QUANTUM INTERFERENCE DEVICE (SQUID) MICROSCOPY

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