INTERACTIONS OF TYPE II TOPOISOMERASES WITH DIVALENT METAL IONS AND THERAPEUTIC DRUGS
All living organisms encode at least one type II topoisomerase. These enzymes help to regulate the superhelical density of the bacterial chromosome and remove knots and tangles from the double helix. Previous studies indicate that eukaryotic type II enzymes utilize a novel variant of the canonical t...
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| Language: | en |
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VANDERBILT
2011
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-07072011-173044/ |