INVESTIGATIONS INTO ISLET PDX1 ACTIVITY: CONTRIBUTION TO MATURE β-CELL IDENTITY AND THE IDENTIFICATION AND CHARACTERIZATION OF PDX1 COREGULATORS
Pdx1 is a transcription factor of fundamental importance to pancreas formation and adult islet ?-cell function. However, little is known regarding its role in mature b-cells or the positive- and negative-acting coregulators recruited to mediate transcriptional control. Using a conditional deletion a...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2015
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-05272015-163131/ |