Cellular Metabolism Contributes To Therapeutic Responses in BRAF-Mutated Melanomas

Cellular Metabolism Contributes To Therapeutic Responses in BRAF-Mutated Melanomas

Melanoma is the deadliest form of skin cancer, and virtually all patients progress on targeted therapies. Dysregulated metabolism has been shown to affect therapy response, so BRAF-mutated melanoma cell line models were used to connect cellular metabolism to therapeutic proliferative response. The d...

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Main Author: Hardeman, Keisha Nicole
Other Authors: Joshua Fessel
Format: Others
Language:en
Published: VANDERBILT 2017
Subjects:
Cancer Biology
Online Access:http://etd.library.vanderbilt.edu/available/etd-04112017-094307/
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spelling ndltd-VANDERBILT-oai-VANDERBILTETD-etd-04112017-0943072017-04-12T05:34:38Z Cellular Metabolism Contributes To Therapeutic Responses in BRAF-Mutated Melanomas Hardeman, Keisha Nicole Cancer Biology Melanoma is the deadliest form of skin cancer, and virtually all patients progress on targeted therapies. Dysregulated metabolism has been shown to affect therapy response, so BRAF-mutated melanoma cell line models were used to connect cellular metabolism to therapeutic proliferative response. The data show that forcing a glycolytic metabolic strategy in the context of drug treatment enhances the antitumor effect. Anti-retrovirals, particularly zalcitabine, were shown to dramatically affect proliferation when combined with BRAF inhibitor. All in all, this dissertation provides an important contribution to response variability and assay development, the glycolytic biology in relation to BRAF inhibition, and a finer inspection of variability within a tumor. Joshua Fessel Jamey Young Christopher Chad Quarles Vito Quaranta Kimberly Dahlman Ann Richmond VANDERBILT 2017-04-11 text application/pdf http://etd.library.vanderbilt.edu/available/etd-04112017-094307/ http://etd.library.vanderbilt.edu/available/etd-04112017-094307/ en unrestricted I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.
collection NDLTD
language en
format Others
sources NDLTD
topic Cancer Biology
spellingShingle Cancer Biology
Hardeman, Keisha Nicole
Cellular Metabolism Contributes To Therapeutic Responses in BRAF-Mutated Melanomas
description Melanoma is the deadliest form of skin cancer, and virtually all patients progress on targeted therapies. Dysregulated metabolism has been shown to affect therapy response, so BRAF-mutated melanoma cell line models were used to connect cellular metabolism to therapeutic proliferative response. The data show that forcing a glycolytic metabolic strategy in the context of drug treatment enhances the antitumor effect. Anti-retrovirals, particularly zalcitabine, were shown to dramatically affect proliferation when combined with BRAF inhibitor. All in all, this dissertation provides an important contribution to response variability and assay development, the glycolytic biology in relation to BRAF inhibition, and a finer inspection of variability within a tumor.
author2 Joshua Fessel
author_facet Joshua Fessel
Hardeman, Keisha Nicole
author Hardeman, Keisha Nicole
author_sort Hardeman, Keisha Nicole
title Cellular Metabolism Contributes To Therapeutic Responses in BRAF-Mutated Melanomas
title_short Cellular Metabolism Contributes To Therapeutic Responses in BRAF-Mutated Melanomas
title_full Cellular Metabolism Contributes To Therapeutic Responses in BRAF-Mutated Melanomas
title_fullStr Cellular Metabolism Contributes To Therapeutic Responses in BRAF-Mutated Melanomas
title_full_unstemmed Cellular Metabolism Contributes To Therapeutic Responses in BRAF-Mutated Melanomas
title_sort cellular metabolism contributes to therapeutic responses in braf-mutated melanomas
publisher VANDERBILT
publishDate 2017
url http://etd.library.vanderbilt.edu/available/etd-04112017-094307/
work_keys_str_mv AT hardemankeishanicole cellularmetabolismcontributestotherapeuticresponsesinbrafmutatedmelanomas
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