Computational Analysis of Cyclooxygenase Inhibition: Energetics and Dynamics
The cyclooxygenase (COX) enzyme catalyzes the bis-dioxygenation and cyclization of arachidonic acid to form prostaglandin H2, the common precursor of bioactive prostaglandins. The genome codes two 60% sequence-identical COX isoforms. COX-1 is constitutively expressed and is associated with maintenan...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2008
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-04112008-120250/ |