Clustering Rare Event Features to Increase Statistical Power

Rare genetic variation has been put forward as a major contributor to the development of disease; however, it is inherently difficult to associate rare variants with disease, as the low number of observations greatly reduces statistical power. Binning is a method that groups several variants togethe...

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Bibliographic Details
Main Author: Sivley, Robert Michael
Other Authors: Dr. Tricia A. Thornton-Wells
Format: Others
Language:en
Published: VANDERBILT 2013
Subjects:
Online Access:http://etd.library.vanderbilt.edu/available/etd-04082013-143931/