Multi-exponential T2 Myelin Water Imaging in Ex-Vivo Rodent Brain at 7T and 15.2T

Multi-exponential T2 Myelin Water Imaging in Ex-Vivo Rodent Brain at 7T and 15.2T

To apply MWI techniques to excised, fixed rodent brains, multi-exponential T2 (MET2) data were acquired at high (7T) and ultra-high (15.2T) fields with and without tissue doping with Gadolinium to increase SNR efficiency. From relaxivity measurements, optimal scan parameters are found based on the m...

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Bibliographic Details
Main Author: West, Kathryn Louise
Other Authors: Mark D. Does
Format: Others
Language:en
Published: VANDERBILT 2014
Subjects:
Biomedical Engineering
Online Access:http://etd.library.vanderbilt.edu/available/etd-03252014-084553/
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spelling ndltd-VANDERBILT-oai-VANDERBILTETD-etd-03252014-0845532014-04-17T05:06:49Z Multi-exponential T2 Myelin Water Imaging in Ex-Vivo Rodent Brain at 7T and 15.2T West, Kathryn Louise Biomedical Engineering To apply MWI techniques to excised, fixed rodent brains, multi-exponential T2 (MET2) data were acquired at high (7T) and ultra-high (15.2T) fields with and without tissue doping with Gadolinium to increase SNR efficiency. From relaxivity measurements, optimal scan parameters are found based on the minimal Cramér-Rao lower bounds (CRLB) of variance of myelin water fraction (MWF). Subsequently acquired MET2 data were analyzed to obtain myelin water fraction (MWF) maps with and without contrast agent at each field strength with various techniques, displaying the potential for MWI in rodent brain in the study of myelin content across whole brain. Mark D. Does Daniel F. Gochberg VANDERBILT 2014-04-16 text application/pdf http://etd.library.vanderbilt.edu/available/etd-03252014-084553/ http://etd.library.vanderbilt.edu/available/etd-03252014-084553/ en restricted I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.
collection NDLTD
language en
format Others
sources NDLTD
topic Biomedical Engineering
spellingShingle Biomedical Engineering
West, Kathryn Louise
Multi-exponential T2 Myelin Water Imaging in Ex-Vivo Rodent Brain at 7T and 15.2T
description To apply MWI techniques to excised, fixed rodent brains, multi-exponential T2 (MET2) data were acquired at high (7T) and ultra-high (15.2T) fields with and without tissue doping with Gadolinium to increase SNR efficiency. From relaxivity measurements, optimal scan parameters are found based on the minimal Cramér-Rao lower bounds (CRLB) of variance of myelin water fraction (MWF). Subsequently acquired MET2 data were analyzed to obtain myelin water fraction (MWF) maps with and without contrast agent at each field strength with various techniques, displaying the potential for MWI in rodent brain in the study of myelin content across whole brain.
author2 Mark D. Does
author_facet Mark D. Does
West, Kathryn Louise
author West, Kathryn Louise
author_sort West, Kathryn Louise
title Multi-exponential T2 Myelin Water Imaging in Ex-Vivo Rodent Brain at 7T and 15.2T
title_short Multi-exponential T2 Myelin Water Imaging in Ex-Vivo Rodent Brain at 7T and 15.2T
title_full Multi-exponential T2 Myelin Water Imaging in Ex-Vivo Rodent Brain at 7T and 15.2T
title_fullStr Multi-exponential T2 Myelin Water Imaging in Ex-Vivo Rodent Brain at 7T and 15.2T
title_full_unstemmed Multi-exponential T2 Myelin Water Imaging in Ex-Vivo Rodent Brain at 7T and 15.2T
title_sort multi-exponential t2 myelin water imaging in ex-vivo rodent brain at 7t and 15.2t
publisher VANDERBILT
publishDate 2014
url http://etd.library.vanderbilt.edu/available/etd-03252014-084553/
work_keys_str_mv AT westkathrynlouise multiexponentialt2myelinwaterimaginginexvivorodentbrainat7tand152t
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