Analyzing the mechanisms of LMO2-induced T-cell leukemia and the functional dissection of the LMO2 target HHEX in adult hematopoiesis
LIM domain Only-2 (LMO2) is a T cell oncogene whose molecular mechanism for T-cell transformation still remains to be elucidated. There are two hypotheses that could explain how the enforced expression of LMO2 induces T-cell Acute Lymphoblastic Leukemia (T-ALL). The first hypothesis is that LMO2 enf...
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| Format: | Others |
| Language: | en |
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VANDERBILT
2015
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| Online Access: | http://etd.library.vanderbilt.edu/available/etd-03082015-161612/ |