Electrospray ionization tandem mass spectrometry methods for the analysis of DNA and DNA/drug complexes

Electrospray ionization tandem mass spectrometry methods for the analysis of DNA and DNA/drug complexes

Many anticancer therapies are based on the interaction of small molecule drugs with nucleic acids, particularly DNA. Electrospray ionization tandem mass spectrometry has established itself as an irreplaceable tool for the characterization of DNA adducts produced by alkylating agents, carcinogens, an...

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Bibliographic Details
Main Author: Smith, Suncerae I.
Format: Others
Language:English
Published: 2010
Subjects:
Electrospray ionization mass spectrometry
DNA
DNA/drug
RNA
Tandem mass spectrometry
Collision induced dissociation
Infrared multiphoton dissociation
Ultraviolet photodissociation
Electron transfer dissociation
Online Access:http://hdl.handle.net/2152/ETD-UT-2010-08-1804

Internet

http://hdl.handle.net/2152/ETD-UT-2010-08-1804

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