Design, synthesis, and calorimetric studies on protein-ligand interactions : apolar surface area, conformational constraints, and application of the Topliss decision tree
A preorganised amino acid derivative containing a cyclopropyl constraint was designed to orient an amino acid into its bound conformation. This constrained mimic was determined by ITC to be equally potent to the native Phe derivative. It was found that a more favorable enthalpy of binding was compen...
| Main Author: | |
|---|---|
| Format: | Others |
| Published: |
2014
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/2152/26603 |