Studies directed towards the synthesis of (±)-nakadomarin A

Herein is described our synthetic efforts toward the synthesis of (±)-nakadomarin A, a member of the manzamine alkaloids. The first chapter describes the isolation and biological significance of (–)-nakadomarin A. Chapter 2 describes the previous total syntheses as well as other partial syntheses of...

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Main Author:	Garizi, Negar Vosoogh, 1978-
Format:	Others
Language:	English
Published:	2012
Subjects:	Alkaloids > Synthesis Scission (Chemistry)
Online Access:	http://hdl.handle.net/2152/17856

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record_format	oai_dc
spelling	ndltd-UTEXAS-oai-repositories.lib.utexas.edu-2152-178562015-09-20T17:09:42ZStudies directed towards the synthesis of (±)-nakadomarin AGarizi, Negar Vosoogh, 1978-Alkaloids--SynthesisScission (Chemistry)Herein is described our synthetic efforts toward the synthesis of (±)-nakadomarin A, a member of the manzamine alkaloids. The first chapter describes the isolation and biological significance of (–)-nakadomarin A. Chapter 2 describes the previous total syntheses as well as other partial syntheses of both (–)-nakadomarin A and its unnatural enantiomer. Chapter 3 discusses our approach to the formation of rings A and B in nakadomarin, as well as the installation of the quaternary center and the regioselective incorporation of a hydrazine moiety. Chapter 4 contains the development of a new methodology for the cleavage of hydrazine N-N bonds situated alpha to a carbonyl functionality. Chapter 5 describes the formation of rings D and E. Chapter 6 consists of experimental details and characterization data for all new compounds.text2012-09-11T14:07:00Z2012-09-11T14:07:00Z2008-082012-09-11electronichttp://hdl.handle.net/2152/17856engCopyright is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.
collection	NDLTD
language	English
format	Others
sources	NDLTD
topic	Alkaloids--Synthesis Scission (Chemistry)
spellingShingle	Alkaloids--Synthesis Scission (Chemistry) Garizi, Negar Vosoogh, 1978- Studies directed towards the synthesis of (±)-nakadomarin A
description	Herein is described our synthetic efforts toward the synthesis of (±)-nakadomarin A, a member of the manzamine alkaloids. The first chapter describes the isolation and biological significance of (–)-nakadomarin A. Chapter 2 describes the previous total syntheses as well as other partial syntheses of both (–)-nakadomarin A and its unnatural enantiomer. Chapter 3 discusses our approach to the formation of rings A and B in nakadomarin, as well as the installation of the quaternary center and the regioselective incorporation of a hydrazine moiety. Chapter 4 contains the development of a new methodology for the cleavage of hydrazine N-N bonds situated alpha to a carbonyl functionality. Chapter 5 describes the formation of rings D and E. Chapter 6 consists of experimental details and characterization data for all new compounds. === text
author	Garizi, Negar Vosoogh, 1978-
author_facet	Garizi, Negar Vosoogh, 1978-
author_sort	Garizi, Negar Vosoogh, 1978-
title	Studies directed towards the synthesis of (±)-nakadomarin A
title_short	Studies directed towards the synthesis of (±)-nakadomarin A
title_full	Studies directed towards the synthesis of (±)-nakadomarin A
title_fullStr	Studies directed towards the synthesis of (±)-nakadomarin A
title_full_unstemmed	Studies directed towards the synthesis of (±)-nakadomarin A
title_sort	studies directed towards the synthesis of (±)-nakadomarin a
publishDate	2012
url	http://hdl.handle.net/2152/17856
work_keys_str_mv	AT garizinegarvosoogh1978 studiesdirectedtowardsthesynthesisofnakadomarina
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Studies directed towards the synthesis of (±)-nakadomarin A

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