Mechanisms underlying the dysregulation of postural stability in dopamine-depleted rates

The work described in this dissertation aims to understand how postural instability (PI), a troubling symptom of advanced Parkinson's disease (PD) in humans, develops from the degeneration of nigrostriatal dopamine neurons characteristic of PD. The studies herein (1) outline the development of...

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Main Author: Woodlee, Martin Thomas, 1977-
Format: Others
Language:English
Published: 2012
Subjects:
Online Access:http://hdl.handle.net/2152/17830
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spelling ndltd-UTEXAS-oai-repositories.lib.utexas.edu-2152-178302015-09-20T17:09:22ZMechanisms underlying the dysregulation of postural stability in dopamine-depleted ratesWoodlee, Martin Thomas, 1977-EquilibriumDopamineParkinson's disease--Animal modelsThe work described in this dissertation aims to understand how postural instability (PI), a troubling symptom of advanced Parkinson's disease (PD) in humans, develops from the degeneration of nigrostriatal dopamine neurons characteristic of PD. The studies herein (1) outline the development of clinically relevant methods for evaluating PI in experimental rodents, (2) indicate that PI may not result directly from disruption of dopamine systems but may instead arise from non-dopaminergic changes that occur subsequent to dopamine depletion, and (3) search for specific evidence of plasticity or degeneration outside of the damaged nigrostriatal dopamine system that may be linked to the development of PI. It is hoped that this work will help lay the foundation for the development of novel prophylactic treatments aimed at preventing the progression of PD to advanced stages where treatment-resistant symptoms such as PI appear.text2012-09-10T17:31:55Z2012-09-10T17:31:55Z2008-052012-09-10electronichttp://hdl.handle.net/2152/17830engCopyright is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.
collection NDLTD
language English
format Others
sources NDLTD
topic Equilibrium
Dopamine
Parkinson's disease--Animal models
spellingShingle Equilibrium
Dopamine
Parkinson's disease--Animal models
Woodlee, Martin Thomas, 1977-
Mechanisms underlying the dysregulation of postural stability in dopamine-depleted rates
description The work described in this dissertation aims to understand how postural instability (PI), a troubling symptom of advanced Parkinson's disease (PD) in humans, develops from the degeneration of nigrostriatal dopamine neurons characteristic of PD. The studies herein (1) outline the development of clinically relevant methods for evaluating PI in experimental rodents, (2) indicate that PI may not result directly from disruption of dopamine systems but may instead arise from non-dopaminergic changes that occur subsequent to dopamine depletion, and (3) search for specific evidence of plasticity or degeneration outside of the damaged nigrostriatal dopamine system that may be linked to the development of PI. It is hoped that this work will help lay the foundation for the development of novel prophylactic treatments aimed at preventing the progression of PD to advanced stages where treatment-resistant symptoms such as PI appear. === text
author Woodlee, Martin Thomas, 1977-
author_facet Woodlee, Martin Thomas, 1977-
author_sort Woodlee, Martin Thomas, 1977-
title Mechanisms underlying the dysregulation of postural stability in dopamine-depleted rates
title_short Mechanisms underlying the dysregulation of postural stability in dopamine-depleted rates
title_full Mechanisms underlying the dysregulation of postural stability in dopamine-depleted rates
title_fullStr Mechanisms underlying the dysregulation of postural stability in dopamine-depleted rates
title_full_unstemmed Mechanisms underlying the dysregulation of postural stability in dopamine-depleted rates
title_sort mechanisms underlying the dysregulation of postural stability in dopamine-depleted rates
publishDate 2012
url http://hdl.handle.net/2152/17830
work_keys_str_mv AT woodleemartinthomas1977 mechanismsunderlyingthedysregulationofposturalstabilityindopaminedepletedrates
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