An Alternate and Facile Method for the Synthesis of Precursors of 3- and 6- Aminosugar Donors and a One-Pot Glycosylation Approach

The synthesis of 3- and 6- aminosugars from the old route requires many synthetic steps and is challenging. An alternative approach is to utilize acid-catalyzed hydrolysis of kanamycin derivatives. The 3-and 6 aminosugar donor was synthesized in just two steps with excellent yield and cost-effective...

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Main Author:	Pandey, Uddav
Format:	Others
Published:	DigitalCommons@USU 2019
Subjects:	3-aminosugar 6- aminosugar Kanamycin-hydrolysis Glycosylation
Online Access:	https://digitalcommons.usu.edu/etd/7692 https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=8820&context=etd

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spelling	ndltd-UTAHS-oai-digitalcommons.usu.edu-etd-88202019-12-07T03:54:12Z An Alternate and Facile Method for the Synthesis of Precursors of 3- and 6- Aminosugar Donors and a One-Pot Glycosylation Approach Pandey, Uddav The synthesis of 3- and 6- aminosugars from the old route requires many synthetic steps and is challenging. An alternative approach is to utilize acid-catalyzed hydrolysis of kanamycin derivatives. The 3-and 6 aminosugar donor was synthesized in just two steps with excellent yield and cost-effective. The acidic hydrolysis of these aminoglycosides provided not only the 3-and 6-aminosugars, but the direct chemical glycosylation of these aminosugars was proven feasible using isopropanol and octanol as the acceptor. 2019-12-01T08:00:00Z text application/pdf https://digitalcommons.usu.edu/etd/7692 https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=8820&context=etd Copyright for this work is held by the author. Transmission or reproduction of materials protected by copyright beyond that allowed by fair use requires the written permission of the copyright owners. Works not in the public domain cannot be commercially exploited without permission of the copyright owner. Responsibility for any use rests exclusively with the user. For more information contact digitalcommons@usu.edu. All Graduate Theses and Dissertations DigitalCommons@USU 3-aminosugar 6- aminosugar Kanamycin-hydrolysis Glycosylation
collection	NDLTD
format	Others
sources	NDLTD
topic	3-aminosugar 6- aminosugar Kanamycin-hydrolysis Glycosylation
spellingShingle	3-aminosugar 6- aminosugar Kanamycin-hydrolysis Glycosylation Pandey, Uddav An Alternate and Facile Method for the Synthesis of Precursors of 3- and 6- Aminosugar Donors and a One-Pot Glycosylation Approach
description	The synthesis of 3- and 6- aminosugars from the old route requires many synthetic steps and is challenging. An alternative approach is to utilize acid-catalyzed hydrolysis of kanamycin derivatives. The 3-and 6 aminosugar donor was synthesized in just two steps with excellent yield and cost-effective. The acidic hydrolysis of these aminoglycosides provided not only the 3-and 6-aminosugars, but the direct chemical glycosylation of these aminosugars was proven feasible using isopropanol and octanol as the acceptor.
author	Pandey, Uddav
author_facet	Pandey, Uddav
author_sort	Pandey, Uddav
title	An Alternate and Facile Method for the Synthesis of Precursors of 3- and 6- Aminosugar Donors and a One-Pot Glycosylation Approach
title_short	An Alternate and Facile Method for the Synthesis of Precursors of 3- and 6- Aminosugar Donors and a One-Pot Glycosylation Approach
title_full	An Alternate and Facile Method for the Synthesis of Precursors of 3- and 6- Aminosugar Donors and a One-Pot Glycosylation Approach
title_fullStr	An Alternate and Facile Method for the Synthesis of Precursors of 3- and 6- Aminosugar Donors and a One-Pot Glycosylation Approach
title_full_unstemmed	An Alternate and Facile Method for the Synthesis of Precursors of 3- and 6- Aminosugar Donors and a One-Pot Glycosylation Approach
title_sort	alternate and facile method for the synthesis of precursors of 3- and 6- aminosugar donors and a one-pot glycosylation approach
publisher	DigitalCommons@USU
publishDate	2019
url	https://digitalcommons.usu.edu/etd/7692 https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=8820&context=etd
work_keys_str_mv	AT pandeyuddav analternateandfacilemethodforthesynthesisofprecursorsof3and6aminosugardonorsandaonepotglycosylationapproach AT pandeyuddav alternateandfacilemethodforthesynthesisofprecursorsof3and6aminosugardonorsandaonepotglycosylationapproach
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An Alternate and Facile Method for the Synthesis of Precursors of 3- and 6- Aminosugar Donors and a One-Pot Glycosylation Approach

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