An Alternate and Facile Method for the Synthesis of Precursors of 3- and 6- Aminosugar Donors and a One-Pot Glycosylation Approach
The synthesis of 3- and 6- aminosugars from the old route requires many synthetic steps and is challenging. An alternative approach is to utilize acid-catalyzed hydrolysis of kanamycin derivatives. The 3-and 6 aminosugar donor was synthesized in just two steps with excellent yield and cost-effective...
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| Format: | Others |
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DigitalCommons@USU
2019
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| Online Access: | https://digitalcommons.usu.edu/etd/7692 https://digitalcommons.usu.edu/cgi/viewcontent.cgi?article=8820&context=etd |
| Summary: | The synthesis of 3- and 6- aminosugars from the old route requires many synthetic steps and is challenging. An alternative approach is to utilize acid-catalyzed hydrolysis of kanamycin derivatives. The 3-and 6 aminosugar donor was synthesized in just two steps with excellent yield and cost-effective. The acidic hydrolysis of these aminoglycosides provided not only the 3-and 6-aminosugars, but the direct chemical glycosylation of these aminosugars was proven feasible using isopropanol and octanol as the acceptor. |
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