Biomarker Detection at Risk Forecasting Level Using Metal-Enhanced Fluorescence Combined with Surface Acoustic Wave

Biomarker Detection at Risk Forecasting Level Using Metal-Enhanced Fluorescence Combined with Surface Acoustic Wave

In this paper, metal-enhanced fluorescence (MEF) technique is used to lower the detection limit of carcinoembryonic antigen (CEA) which is able to be utilized in forecasting the risk of having certain kinds of cancers, especially colon and rectal cancer. By incubating silver nanocubes (Ag NCs) on th...

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Bibliographic Details
Main Author: Liu, Jun
Format: Others
Published: Scholar Commons 2016
Subjects:
Silver Nanocubes
CEA
Immunofluorescence
Biotechnology
Limit of Detection
Biomedical Engineering and Bioengineering
Chemical Engineering
Materials Science and Engineering
Online Access:http://scholarcommons.usf.edu/etd/6534
http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=7731&context=etd
Description
Summary:In this paper, metal-enhanced fluorescence (MEF) technique is used to lower the detection limit of carcinoembryonic antigen (CEA) which is able to be utilized in forecasting the risk of having certain kinds of cancers, especially colon and rectal cancer. By incubating silver nanocubes (Ag NCs) on the surface of the chips, the detection limit goes down to below 1ng/mL of CEA. Also, when combining MEF with surface acoustic wave (SAW) devices, the incubation time between antigen and antibody will decrease significantly with the fluorescence signal keeping similar or higher level.

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