Human miRNA Sequence Based Variations Database

MicroRNAs (miRNAs) are studied as key genetic elements that regulate the gene expression involved in different human diseases. Clinical sequence based variations like copy number variations (CNVs) affect miRNA biogenesis, dosage and target recognition that may represent potentially functional varian...

Full description

Bibliographic Details
Main Author: Bou Zeidan, Nadim Georges
Format: Others
Published: Scholar Commons 2014
Subjects:
CNV
Online Access:https://scholarcommons.usf.edu/etd/5350
https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=6543&context=etd
id ndltd-USF-oai-scholarcommons.usf.edu-etd-6543
record_format oai_dc
spelling ndltd-USF-oai-scholarcommons.usf.edu-etd-65432019-10-04T05:10:12Z Human miRNA Sequence Based Variations Database Bou Zeidan, Nadim Georges MicroRNAs (miRNAs) are studied as key genetic elements that regulate the gene expression involved in different human diseases. Clinical sequence based variations like copy number variations (CNVs) affect miRNA biogenesis, dosage and target recognition that may represent potentially functional variants and relevant target bindings. To systematically analyze miRNA-related CNVs and their effects on related genes, a user-friendly free online database was developed to provide further analysis of co-localization of miRNA loci with human genome CNV regions. Further analysis pipelines such as miRNA-target to estimate the levels or locations of variations for genetic duplications, insertions or deletions were also offered. Such information could support the simulation of miRNA-target interactions. 2014-10-22T07:00:00Z text application/pdf https://scholarcommons.usf.edu/etd/5350 https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=6543&context=etd default Graduate Theses and Dissertations Scholar Commons CNV Frequency Human Genome Nucleotide Polymorphisms Computer Engineering
collection NDLTD
format Others
sources NDLTD
topic CNV
Frequency
Human Genome
Nucleotide Polymorphisms
Computer Engineering
spellingShingle CNV
Frequency
Human Genome
Nucleotide Polymorphisms
Computer Engineering
Bou Zeidan, Nadim Georges
Human miRNA Sequence Based Variations Database
description MicroRNAs (miRNAs) are studied as key genetic elements that regulate the gene expression involved in different human diseases. Clinical sequence based variations like copy number variations (CNVs) affect miRNA biogenesis, dosage and target recognition that may represent potentially functional variants and relevant target bindings. To systematically analyze miRNA-related CNVs and their effects on related genes, a user-friendly free online database was developed to provide further analysis of co-localization of miRNA loci with human genome CNV regions. Further analysis pipelines such as miRNA-target to estimate the levels or locations of variations for genetic duplications, insertions or deletions were also offered. Such information could support the simulation of miRNA-target interactions.
author Bou Zeidan, Nadim Georges
author_facet Bou Zeidan, Nadim Georges
author_sort Bou Zeidan, Nadim Georges
title Human miRNA Sequence Based Variations Database
title_short Human miRNA Sequence Based Variations Database
title_full Human miRNA Sequence Based Variations Database
title_fullStr Human miRNA Sequence Based Variations Database
title_full_unstemmed Human miRNA Sequence Based Variations Database
title_sort human mirna sequence based variations database
publisher Scholar Commons
publishDate 2014
url https://scholarcommons.usf.edu/etd/5350
https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=6543&context=etd
work_keys_str_mv AT bouzeidannadimgeorges humanmirnasequencebasedvariationsdatabase
_version_ 1719260154532200448