Human miRNA Sequence Based Variations Database
MicroRNAs (miRNAs) are studied as key genetic elements that regulate the gene expression involved in different human diseases. Clinical sequence based variations like copy number variations (CNVs) affect miRNA biogenesis, dosage and target recognition that may represent potentially functional varian...
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| Format: | Others |
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Scholar Commons
2014
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| Online Access: | https://scholarcommons.usf.edu/etd/5350 https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=6543&context=etd |
| Summary: | MicroRNAs (miRNAs) are studied as key genetic elements that regulate the gene expression involved in different human diseases. Clinical sequence based variations like copy number variations (CNVs) affect miRNA biogenesis, dosage and target recognition that may represent potentially functional variants and relevant target bindings.
To systematically analyze miRNA-related CNVs and their effects on related genes, a user-friendly free online database was developed to provide further analysis of co-localization of miRNA loci with human genome CNV regions. Further analysis pipelines such as miRNA-target to estimate the levels or locations of variations for genetic duplications, insertions or deletions were also offered. Such information could support the simulation of miRNA-target interactions. |
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