The association of head circumference with selected cognitive outcomes in older adults in Charlotte County, Florida

OBJECTIVE: The brain reserve hypothesis was examined in a secondary analysis of cross-sectional data from a community-based sample of 468 older adults residing in Charlotte County, Florida. The objective of the analysis was to determine the association between head circumference and eight cognitive...

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Main Author: Copenhaver, Cathleen
Format: Others
Published: Scholar Commons 2006
Subjects:
3MS
Online Access:http://scholarcommons.usf.edu/etd/2490
http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=3489&context=etd
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spelling ndltd-USF-oai-scholarcommons.usf.edu-etd-34892015-09-30T04:39:24Z The association of head circumference with selected cognitive outcomes in older adults in Charlotte County, Florida Copenhaver, Cathleen OBJECTIVE: The brain reserve hypothesis was examined in a secondary analysis of cross-sectional data from a community-based sample of 468 older adults residing in Charlotte County, Florida. The objective of the analysis was to determine the association between head circumference and eight cognitive outcomes and to assess any potential effect modification of existing associations by Apolipoprotein E (APOE) genotype. METHODS: Cognitive outcomes include scores from the Modified Mini-Mental State Exam (3MS), the Hopkins Verbal Learning Test-Revised (HVLT-R), Stroop Color-Word Test, Trail-Making Test A and B, and a word-stem completion task measuring implicit memory. Descriptive statistics were calculated for each variable. Head circumference and dependent cognitive outcomes were modeled as dichotomous variables using logistic regression, adjusting for gender, age, education, income, height, and Spot The Word test score, a measure of pre-morbid IQ. For dichotomized test scores, poor outcomes (cases) were defined as having scores in the lowest quintile; the remaining top four quintiles were considered non-cases. RESULTS: small head circumference was significantly associated with low 3MS scores [OR(95%CI): 2.97 (1.12, 7.89), p=0.03], after adjustment for age, income and pre-morbid IQ. The association remained statistically significant after adjustment for gender and education as well. After adjustment, head circumference was not found to be statistically significantly associated with any other cognitive outcome. No effect modification was found by APOE genotype or years of education. CONCLUSION: This analysis confirms previous findings that exposure to low head circumference significantly impacts cognition in late life. 2006-06-01T07:00:00Z text application/pdf http://scholarcommons.usf.edu/etd/2490 http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=3489&context=etd default Graduate Theses and Dissertations Scholar Commons Brain reserve Alzheimer's disease Aging 3MS Apolipoprotein E American Studies Arts and Humanities
collection NDLTD
format Others
sources NDLTD
topic Brain reserve
Alzheimer's disease
Aging
3MS
Apolipoprotein E
American Studies
Arts and Humanities
spellingShingle Brain reserve
Alzheimer's disease
Aging
3MS
Apolipoprotein E
American Studies
Arts and Humanities
Copenhaver, Cathleen
The association of head circumference with selected cognitive outcomes in older adults in Charlotte County, Florida
description OBJECTIVE: The brain reserve hypothesis was examined in a secondary analysis of cross-sectional data from a community-based sample of 468 older adults residing in Charlotte County, Florida. The objective of the analysis was to determine the association between head circumference and eight cognitive outcomes and to assess any potential effect modification of existing associations by Apolipoprotein E (APOE) genotype. METHODS: Cognitive outcomes include scores from the Modified Mini-Mental State Exam (3MS), the Hopkins Verbal Learning Test-Revised (HVLT-R), Stroop Color-Word Test, Trail-Making Test A and B, and a word-stem completion task measuring implicit memory. Descriptive statistics were calculated for each variable. Head circumference and dependent cognitive outcomes were modeled as dichotomous variables using logistic regression, adjusting for gender, age, education, income, height, and Spot The Word test score, a measure of pre-morbid IQ. For dichotomized test scores, poor outcomes (cases) were defined as having scores in the lowest quintile; the remaining top four quintiles were considered non-cases. RESULTS: small head circumference was significantly associated with low 3MS scores [OR(95%CI): 2.97 (1.12, 7.89), p=0.03], after adjustment for age, income and pre-morbid IQ. The association remained statistically significant after adjustment for gender and education as well. After adjustment, head circumference was not found to be statistically significantly associated with any other cognitive outcome. No effect modification was found by APOE genotype or years of education. CONCLUSION: This analysis confirms previous findings that exposure to low head circumference significantly impacts cognition in late life.
author Copenhaver, Cathleen
author_facet Copenhaver, Cathleen
author_sort Copenhaver, Cathleen
title The association of head circumference with selected cognitive outcomes in older adults in Charlotte County, Florida
title_short The association of head circumference with selected cognitive outcomes in older adults in Charlotte County, Florida
title_full The association of head circumference with selected cognitive outcomes in older adults in Charlotte County, Florida
title_fullStr The association of head circumference with selected cognitive outcomes in older adults in Charlotte County, Florida
title_full_unstemmed The association of head circumference with selected cognitive outcomes in older adults in Charlotte County, Florida
title_sort association of head circumference with selected cognitive outcomes in older adults in charlotte county, florida
publisher Scholar Commons
publishDate 2006
url http://scholarcommons.usf.edu/etd/2490
http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=3489&context=etd
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