Studies in Rhodium Catalyzed Intramolecular C-H Insertion of Amino Acid Derived α-Diazo-α-(substituted)acetamides and its Application to the Total Synthesis of <em>clasto</em>-Lactacystin β-Lactone
Lactacystin is a microbial metabolite isolated by Omura that exhibits neurotrophic activity in neuroblastoma cell lines. Lactacystin and especially its β-lactone analog are the first examples of non-polypeptide small molecules capable of specifically inhibiting the 20S proteasome. Various asymmetric...
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| Format: | Others |
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Scholar Commons
2004
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| Online Access: | https://scholarcommons.usf.edu/etd/1037 https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=2036&context=etd |