Multiple Modes of Mdmx Regulation Affect p53 Activation
MDMX has emerged as a negative regulator of p53 transcriptional activity following DNA damage, loss of ribosomal integrity, and aberrant mitogenic signaling. Disruption of rRNA biogenesis by ribosomal stress activates p53 by releasing ribosomal proteins from nucleoli which bind MDM2 and inhibit p53...
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| Format: | Others |
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Scholar Commons
2008
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| Online Access: | https://scholarcommons.usf.edu/etd/260 https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=1259&context=etd |