Scaffolding functions of MAGI-2 in the PTEN mediated attenuation of the PI3K/Akt signalling pathway

Scaffolding functions of MAGI-2 in the PTEN mediated attenuation of the PI3K/Akt signalling pathway

Activated receptor tyrosine kinase (RTK), such as the epidermal growth factor (EGF) receptor (EGFR) and the platelet-derived growth factor (PDGF) receptor (PDGFR), recruit downstream signalling proteins, including phosphatidylinositol 3-kinase (PI3K). PI3K, composed of a regulatory p85 subunit and a...

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Bibliographic Details
Main Author: Poland, Sharon Franceska
Other Authors: Anderson, Deborah H.
Format: Others
Language:en
Published: University of Saskatchewan 2009
Subjects:
PDGFR
cell-signalling
cancer
p85
PI3K
Akt
PTEN
EGFR
MAGI
Online Access:http://library.usask.ca/theses/available/etd-09172009-110738/

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