Determination of the Structural Allosteric Inhibitory Mechanism of Dihydrodipicolinate Synthase

Determination of the Structural Allosteric Inhibitory Mechanism of Dihydrodipicolinate Synthase

Dihydrodipicolinate Synthase (EC 4.3.3.7; DHDPS), the product of the dapA gene, is an enzyme that catalyzes the condensation of pyruvate and S-aspartate-β-semialdehyde (ASA) into dihydrodipicolinate via an unstable heterocyclic intermediate, (4S)-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid. DH...

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Bibliographic Details
Other Authors: Sanders, David A.
Language:English
Published: 2016
Subjects:
protein crystallography
antibiotic drug design
DHDPS
dihydrodipicolinate synthase
Allostery
Campylobacter jejuni
Online Access:http://hdl.handle.net/10388/ETD-2015-11-2317

Internet

http://hdl.handle.net/10388/ETD-2015-11-2317

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