Molecular Simulation of Enzyme Catalysis and Inhibition
The reaction mechanisms for the hemoglobin degrading enzymes in the Plasmodium falciparum malaria parasite, plasmepsin II (Plm II) and histo-aspartic protease (HAP), have been analyzed by molecular simulations. The reaction free energy profiles, calculated by the empirical valence bond (EVB) method...
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| Format: | Doctoral Thesis |
| Language: | English |
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Uppsala universitet, Institutionen för cell- och molekylärbiologi
2007
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| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7468 http://nbn-resolving.de/urn:isbn:978-91-554-6794-6 |