Biopharmaceutical investigations of doxorubicin formulations used in liver cancer treatment : Studies in healthy pigs and liver cancer patients, combined with pharmacokinetic and biopharmaceutical modelling

Biopharmaceutical investigations of doxorubicin formulations used in liver cancer treatment : Studies in healthy pigs and liver cancer patients, combined with pharmacokinetic and biopharmaceutical modelling

There are currently two types of drug formulation in clinical use in the locoregional treatment of intermediate hepatocellular carcinoma (HCC). In the emulsion LIPDOX, the cytostatic agent doxorubicin (DOX) is dissolved in the aqueous phase, which is emulsified with the oily contrast agent Lipiodol®...

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Bibliographic Details
Main Author: Dubbelboer, Ilse R
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för farmaci 2017
Subjects:
drug delivery system
in vivo release
PBPK modelling
hepatocellular carcinoma
doxorubicin
transarterial chemoembolization
drug disposition
Pharmaceutical Sciences
Farmaceutisk vetenskap
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-330953
http://nbn-resolving.de/urn:isbn:978-91-513-0124-2

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-330953
http://nbn-resolving.de/urn:isbn:978-91-513-0124-2

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