Assessing Relationships between Psychological and Biological Markers in Coronary Heart Disease Patients using Bivariate Linear Mixed Models

• Main Author: Lally, Kristine
• Format: Others
• Language: English
• Published: Uppsala universitet, Statistiska institutionen 2017
• Subjects: bivariate linear mixed models; longitudinal outcomes; cognitive behavioral therapy; stress management; Probability Theory and Statistics; Sannolikhetsteori och statistik
• Online Access: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-326015

The Secondary Prevention in Uppsala Primary Health Care Project (SUPRIM) is a randomized controlled trial evaluating the effects of cognitive behavioral therapy on coronary heart disease patients. Various outcomes of psychological and physical health are recorded every six months approximately, over the course of two years after entry to the trial. In this thesis, relationships between the psychological outcome variables, Stress, Anxiety, Depression and Exhaustion, and five physical health biomarkers, are assessed using bivariate linear mixed models. Significant associations are found between one of the biomarkers and both Depression and Exhaustion, and also between one of the other biomarkers and Exhaustion.