Reaction-Diffusion kinetics of Protein DNA Interactions

Reaction-Diffusion kinetics of Protein DNA Interactions

Transcription factors need to rapidly find one specific binding site among millions of nonspecific sites on the chromosomal DNA. In this thesis I use various aspects of reaction-diffusion theory to investigate the interaction between proteins and DNA and to explain the searching, finding and binding...

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Bibliographic Details
Main Author: Mahmutovic, Anel
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Beräknings- och systembiologi 2015
Subjects:
umbrella sampling
molecular dynamics
RDME
PDE
sliding
intersegment transfer
hopping
sterics
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-263527
http://nbn-resolving.de/urn:isbn:978-91-554-9360-8

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-263527
http://nbn-resolving.de/urn:isbn:978-91-554-9360-8

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