Towards Personalized Cancer Therapy : New Diagnostic Biomarkers and Radiosensitization Strategies

Towards Personalized Cancer Therapy : New Diagnostic Biomarkers and Radiosensitization Strategies

This thesis focuses on the evaluation of biomarkers for radio-immunodiagnostics and radio-immunotherapy and on radiosensitization strategies after HSP90 inhibition, as a step towards more personalized cancer medicine. There is a need to develop new tracers that target cancer-specific biomarkers to i...

Full description

Bibliographic Details
Main Author:	Spiegelberg, Diana
Format:	Doctoral Thesis
Language:	English
Published:	Uppsala universitet, Medicinsk strålningsvetenskap 2015
Subjects:	tumor targeting radionuclide targeting HSP90 inhibition AT13387 radiosensitization molecular imaging combination treatment EGFR CD44v6
Online Access:	http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-247539 http://nbn-resolving.de/urn:isbn:978-91-554-9207-6

Similar Items

Inhibition of HSP90 as a Strategy to Radiosensitize Glioblastoma: Targeting the DNA Damage Response and Beyond
by: Michael Orth, et al.
Published: (2021-03-01)

Molecularly Targeted Agents as Radiosensitizers in Cancer Therapy—Focus on Prostate Cancer
by: Phuoc T. Tran, et al.
Published: (2013-07-01)

Improving the Efficacy of Tumor Radiosensitization Through Combined Molecular Targeting
by: Katharina Hintelmann, et al.
Published: (2020-08-01)

Overcoming Limitations of Cisplatin Therapy by Additional Treatment With the HSP90 Inhibitor Onalespib
by: Anja Charlotte Lundgren Mortensen, et al.
Published: (2020-09-01)

Human EGFR-2, EGFR and HDAC triple-inhibitor CUDC-101 enhances radiosensitivity of GBM cells
by: Cody D Schlaff, et al.
Published: (2015-01-01)

MicroRNA-27a downregulates the expression of Hsp90 and enhances the radiosensitivity in esophageal squamous cell carcinoma
by: Wang X, et al.
Published: (2019-07-01)

A systematic organization of bioinformatics database of radiosensitizers and radioprotectors
by: P M Dongre, et al.
Published: (2018-01-01)

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors
by: Nikola Geskovski, et al.
Published: (2021-04-01)

Cell Membrane CD44v6 Levels in Squamous Cell Carcinoma of the Lung: Association with High Cellular Proliferation and High Concentrations of EGFR and CD44v5
by: Álvaro Ruibal, et al.
Published: (2015-02-01)

Synergistic effect of 17-allylamino-17-demethoxygeldanamycin with dehydroxymethylepoxyquinomicin on the human anaplastic thyroid carcinoma cell line KTC2
by: Todorović Lidija, et al.
Published: (2021-01-01)

Targeting molecules for diagnostics of Head and Neck squamous cell carcinoma
by: Haylock, Anna-Karin
Published: (2017)

The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells
by: Andrea Haag, et al.
Published: (2020-02-01)

Discovery and development of natural heat shock protein 90 inhibitors in cancer treatment
by: Yong Li, et al.
Published: (2012-06-01)

Low Dose Rate Radiosensitization of Hepatocellular Carcinoma In Vitro and in Patients
by: Kyle C. Cuneo, et al.
Published: (2014-08-01)

The Role of CD44 in Disease Pathophysiology And Targeted Treatment
by: Andre R. Jordan, et al.
Published: (2015-04-01)

Engineering Modular Half-Antibody Conjugated Nanoparticles for Targeting CD44v6-Expressing Cancer Cells
by: Bianca N. Lourenço, et al.
Published: (2021-01-01)

The Ibr-7 derivative of ibrutinib radiosensitizes pancreatic cancer cells by downregulating p-EGFR
by: Biqin Tan, et al.
Published: (2020-09-01)

Molecular characterization of interdigitating dendritic cell sarcoma
by: Robert J. Penny, et al.
Published: (2010-09-01)

Celastrol Induces Apoptosis in Gefitinib-Resistant Non-Small Cell Lung Cancer Cells via Caspases-Dependent Pathways and Hsp90 Client Protein Degradation
by: Xing-Xing Fan, et al.
Published: (2014-03-01)

Tumor-Targeting Peptides Search Strategy for the Delivery of Therapeutic and Diagnostic Molecules to Tumor Cells
by: Maria D. Dmitrieva, et al.
Published: (2021-12-01)

Antibody-modified liposomes for tumor-targeting delivery of timosaponin AIII
by: Lu L, et al.
Published: (2018-03-01)

Design, Synthesis and In Vitro Investigation of Novel Basic Celastrol Carboxamides as Bio-Inspired Leishmanicidal Agents Endowed with Inhibitory Activity against <i>Leishmania</i> Hsp90
by: Ivan Bassanini, et al.
Published: (2021-01-01)

Histone deacetylase 6 in cancer
by: Ting Li, et al.
Published: (2018-09-01)

Effects of 17-DMAG on Non-small Cell Lung Cancer Cell Lines A549 and H1975 Being Resistant to EGFR-TKI
by: Lei ZHAO, et al.
Published: (2014-11-01)

Honokiol from Magnolia spp. induces G1 arrest via disruption of EGFR stability through repressing HDAC6 deacetylated Hsp90 function in lung cancer cells
by: Shiuan-Fu Liou, et al.
Published: (2015-05-01)

Kajian Heat Shock Protein 90 (HSP90) dalam Pencarian Kandidat Penghambatnya melalui Ekplorasi Bahan Alam Indonesia
by: Rehmadanta Sitepu
Published: (2019-03-01)

Synergistic effects of vorinostat (SAHA) and azoles against Aspergillus species and their biofilms
by: Bo Tu, et al.
Published: (2020-02-01)

Target-Mediated Brain Tissue Binding for Small Molecule Inhibitors of Heat Shock Protein 90
by: Lassina Badolo, et al.
Published: (2020-10-01)

Nimotuzumab promotes radiosensitivity of EGFR-overexpression esophageal squamous cell carcinoma cells by upregulating IGFBP-3
by: Zhao Lei, et al.
Published: (2012-12-01)

D-Propranolol Impairs EGFR Trafficking and Destabilizes Mutant p53 Counteracting AKT Signaling and Tumor Malignancy
by: Jonathan Barra, et al.
Published: (2021-07-01)

HSP90 as a novel molecular target in non-small-cell lung cancer
by: Esfahani K, et al.
Published: (2016-03-01)

Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922
by: Annett Kühnel, et al.
Published: (2019-09-01)

Dissecting Selective Translation of HSP90 mRNA in Mammalian Cells
by: Shaikho, Sarah
Published: (2016)

CD44 Expression Profile Varies According to Maturational Subtypes and Molecular Profiles of Pediatric T-Cell Lymphoblastic Leukemia
by: Luísa Vieira Codeço Marques, et al.
Published: (2018-10-01)

A Bombesin-Shepherdin Radioconjugate Designed for Combined Extra- and Intracellular Targeting
by: Christiane A. Fischer, et al.
Published: (2014-05-01)

CD44 and CD44v6 are Correlated with Gastric Cancer Progression and Poor Patient Prognosis: Evidence from 42 Studies
by: Min Fang, et al.
Published: (2016-11-01)

Combination Therapy, a Promising Approach to Enhance the Efficacy of Radionuclide and Targeted Radionuclide Therapy of Prostate and Breast Cancer
by: Tyrillshall S. T. Damiana, et al.
Published: (2021-05-01)

Design, synthesis, and evaluation of cisplatin-containing EGFR targeting bioconjugates as potential therapeutic agents for brain tumors
by: Barth RF, et al.
Published: (2016-05-01)

Biomarkers for enhancing the radiosensitivity of nasopharyngeal carcinoma
by: Wei Chen, et al.
Published: (2015-03-01)

Expressions of Ezrin and CD44v6 in Gastric Cancer
by: DAI Shi-min
Published: (2014-09-01)