Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors : Targeting Different Genotypes and Drug-Resistant Variants

Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors : Targeting Different Genotypes and Drug-Resistant Variants

Since the first approved hepatitis C virus (HCV) NS3 protease inhibitors in 2011, numerous direct acting antivirals (DAAs) have reached late stages of clinical trials. Today, several combination therapies, based on different DAAs, with or without the need of pegylated interferon-α injection, are ava...

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Bibliographic Details
Main Author:	Belfrage, Anna Karin
Format:	Doctoral Thesis
Language:	English
Published:	Uppsala universitet, Avdelningen för organisk farmaceutisk kemi 2015
Subjects:	hepatitis C virus HCV NS3 protease inhibitors structure-activity relationship 2(1H)-pyrazinone quinazoline resistance Pd catalysis
Online Access:	http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-243317 http://nbn-resolving.de/urn:isbn:978-91-554-9166-6

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