Somatic Mutations in Breast Cancer Genomes : Discovery and Validation of Breast Cancer Genes

Somatic Mutations in Breast Cancer Genomes : Discovery and Validation of Breast Cancer Genes

Breast cancer is the most common cancer in women worldwide. However, the genetic alterations that lead to breast cancer are not fully understood. This thesis aims to identify novel genes of potential mechanistic, diagnostic or therapeutic interest in breast cancers by mutational analysis and whole-g...

Full description

Bibliographic Details
Main Author:	Jiao, Xiang
Format:	Doctoral Thesis
Language:	English
Published:	Uppsala universitet, Institutionen för immunologi, genetik och patologi 2012
Subjects:	breast cancer cancer gene pathway somatic mutation structural alteration sequencing whole genome amplification
Online Access:	http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182319 http://nbn-resolving.de/urn:isbn:978-91-554-8490-3

Similar Items

Association of Body Mass Index With Somatic Mutations in Breast Cancer
by: Bo Chen, et al.
Published: (2021-04-01)

Somatic mutations and copy number variations in breast cancers with heterogeneous HER2 amplification
by: Mieke R. Van Bockstal, et al.
Published: (2020-04-01)

Toward the precision breast cancer survival prediction utilizing combined whole genome-wide expression and somatic mutation analysis
by: Yifan Zhang, et al.
Published: (2018-11-01)

Characterization of AKT Somatic Mutations in Chinese Breast Cancer Patients
by: Wen L, et al.
Published: (2021-04-01)

Integrating Germline and Somatic Mutation Information for the Discovery of Biomarkers in Triple-Negative Breast Cancer
by: Jiande Wu, et al.
Published: (2019-03-01)

Genetic Alterations in Benign Breast Biopsies of Subsequent Breast Cancer Patients
by: Savas D. Soysal, et al.
Published: (2019-07-01)

Targeted next generation sequencing identifies somatic mutations in a cohort of Egyptian breast cancer patients
by: Auhood Nassar, et al.
Published: (2020-07-01)

Somatic mutations in benign breast disease tissues and association with breast cancer risk
by: Stacey J. Winham, et al.
Published: (2021-07-01)

Population-based statistical inference for temporal sequence of somatic mutations in cancer genomes
by: Je-Keun Rhee, et al.
Published: (2018-04-01)

Imprint of parity and age at first pregnancy on the genomic landscape of subsequent breast cancer
by: Bastien Nguyen, et al.
Published: (2019-02-01)

Mutational landscape differences between young-onset and older-onset breast cancer patients
by: Nicole E. Mealey, et al.
Published: (2020-03-01)

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
by: Young Seok Ju, et al.
Published: (2014-10-01)

Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection
by: Anna Y. Lee, et al.
Published: (2018-11-01)

Differential analysis between somatic mutation and germline variation profiles reveals cancer-related genes
by: Pawel F. Przytycki, et al.
Published: (2017-08-01)

Germline PALB2 Mutations in Cancers and Its Distinction From Somatic PALB2 Mutations in Breast Cancers
by: Zhe-Yu Hu, et al.
Published: (2020-08-01)

Characterization of Frequently Mutated Cancer Genes and Tumor Mutation Burden in Chinese Breast Cancer
by: Weikai Xiao, et al.
Published: (2021-04-01)

A knowledge-based framework for the discovery of cancer-predisposing variants using large-scale sequencing breast cancer data
by: Giorgio E. M. Melloni, et al.
Published: (2017-05-01)

Comprehensive Genomic Profile of Heterogeneous Long Follow-Up Triple-Negative Breast Cancer and Its Clinical Characteristics Shows DNA Repair Deficiency Has Better Prognostic
by: Ernesto Rojas-Jiménez, et al.
Published: (2020-11-01)

Landscape of clinically actionable mutations in breast cancer ‘A cohort study’
by: Mithua Ghosh, et al.
Published: (2021-01-01)

Integrating germline and somatic variation information using genomic data for the discovery of biomarkers in prostate cancer
by: Tarun Karthik Kumar Mamidi, et al.
Published: (2019-03-01)

Targeted next-generation sequencing identifies clinically relevant somatic mutations in a large cohort of inflammatory breast cancer
by: Xu Liang, et al.
Published: (2018-08-01)

Deconvolution of the Genomic and Epigenomic Interaction Landscape of Triple-Negative Breast Cancer
by: Jiande Wu, et al.
Published: (2019-10-01)

A Pilot Study for the Feasibility of Exome-Sequencing in Circulating Tumor Cells Versus Single Metastatic Biopsies in Breast Cancer
by: Pushpinder Kaur, et al.
Published: (2020-07-01)

Integrating Somatic Mutations for Breast Cancer Survival Prediction Using Machine Learning Methods
by: Zongzhen He, et al.
Published: (2021-01-01)

Impact of TP53 mutations in breast cancer: Clinicopathological features and prognosisImpact of TP53 mutations in breast CA
by: Xuerui Li, et al.
Published: (2020-07-01)

Difference of molecular alterations in HER2-positive and HER2-negative gastric cancers by whole-genome sequencing analysis
by: Zhou C, et al.
Published: (2018-09-01)

Evaluating somatic tumor mutation detection without matched normal samples
by: Jamie K. Teer, et al.
Published: (2017-09-01)

The somatic mutation landscape of the human body
by: Pablo E. García-Nieto, et al.
Published: (2019-12-01)

Whole-Exome Sequencing Identifies Somatic Mutations Associated With Mortality in Metastatic Clear Cell Kidney Carcinoma
by: Alejandro Mendoza-Alvarez, et al.
Published: (2019-05-01)

Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer
by: Kyong-Ah Yoon, et al.
Published: (2018-12-01)

Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies
by: Sinead Toomey, et al.
Published: (2017-07-01)

Multi-region and single-cell sequencing reveal variable genomic heterogeneity in rectal cancer
by: Mingshan Liu, et al.
Published: (2017-11-01)

Comprehensive Cohort Analysis of Mutational Spectrum in Early Onset Breast Cancer Patients
by: Mohit K. Midha, et al.
Published: (2020-07-01)

Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing
by: Timour Baslan, et al.
Published: (2020-05-01)

Genomic instability at the 13q31 locus and somatic mtDNA mutation in the D-loop site correlate with tumor aggressiveness in sporadic Brazilian breast cancer cases
by: Gilson Costa dos Santos-Jr, et al.
Published: (2012-10-01)

Novel applications of next-generation sequencing in breast cancer research
by: Rong Ma, et al.
Published: (2017-09-01)

Portrait of a cancer: mutational signature analyses for cancer diagnostics
by: Arne Van Hoeck, et al.
Published: (2019-05-01)

CEACAM Gene Family Mutations Associated With Inherited Breast Cancer Risk – A Comparative Oncology Approach to Discovery
by: Anna L. W. Huskey, et al.
Published: (2021-08-01)

Identification of candidate genes for lung cancer somatic mutation test kits
by: Yong Chen, et al.
Published: (2013-01-01)

Putative breast cancer driver mutations in TBX3 cause impaired transcriptional repression
by: Gert O Pflugfelder, et al.
Published: (2015-10-01)

Cannot write session to /tmp/vufind_sessions/sess_1sbc7mj0b7d09ci68jr7a2o0f1