Cyclotides : Tuning Parameters Toward Their Use in Drug Design

Cyclotides : Tuning Parameters Toward Their Use in Drug Design

Cyclotides are plant proteins with a unique topology, defined as the cyclic cystine knot motif. The motif endows cyclotides with exceptional chemical and biological stability. They also exhibit a wide range of biological activities including insecticidal, cytotoxic, anti-HIV and antimicrobial effect...

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Bibliographic Details
Main Author: Yeshak, Mariamawit Yonathan
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet 2012
Subjects:
cyclotide
Viola abyssinica
Viola odorata
Extraction
Violaceae
vaby
cytotoxic
genotoxic
cell penetrating
microautoradiography
LC-MS
comet assay
cycloviolacin O2
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-169712
http://nbn-resolving.de/urn:isbn:978-91-554-8307-4

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-169712
http://nbn-resolving.de/urn:isbn:978-91-554-8307-4

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