Pharmacometric Methods and Novel Models for Discrete Data

Pharmacometric Methods and Novel Models for Discrete Data

Pharmacodynamic processes and disease progression are increasingly characterized with pharmacometric models. However, modelling options for discrete-type responses remain limited, although these response variables are commonly encountered clinical endpoints. Types of data defined as discrete data ar...

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Bibliographic Details
Main Author: Plan, Elodie L
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för farmaceutisk biovetenskap 2011
Subjects:
Pharmacometrics
pharmacodynamics
disease progression
modelling
discrete data
count
ordered categorical
repeated time-to-event
RTTCE
RCEpT
NONMEM
FOCE
LAPLACE
SAEM
AGQ
pain scores
epilepsy seizures
gastroesophageal symptoms
statistical power
simulations
diagnostics
PHARMACY
FARMACI
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150929
http://nbn-resolving.de/urn:isbn:978-91-554-8064-6

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150929
http://nbn-resolving.de/urn:isbn:978-91-554-8064-6

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