Application of Mixed-Effect Modeling to Improve Mechanistic Understanding and Predictability of Oral Absorption

Application of Mixed-Effect Modeling to Improve Mechanistic Understanding and Predictability of Oral Absorption

Several sophisticated techniques to study in vivo GI transit and regional absorption of pharmaceuticals are available and increasingly used. Examples of such methods are Magnetic Marker Monitoring (MMM) and local drug administration with remotely operated capsules. Another approach is the paracetamo...

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Bibliographic Details
Main Author: Bergstrand, Martin
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för farmaceutisk biovetenskap 2011
Subjects:
Absorption
magnetic marker monitoring
drug release
IVIVC
pharmacometrics
NONMEM
model diagnostics
pcVPC
pvcVPC
visual predictive check
VPC
BQL
paracetamol
sulfapyridine.
Other pharmacy
Övrig farmaci
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-149314
http://nbn-resolving.de/urn:isbn:978-91-554-8030-1

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-149314
http://nbn-resolving.de/urn:isbn:978-91-554-8030-1

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