Energetics of cholesterol-modulated membrane permeabilities. A simulation study

Energetics of cholesterol-modulated membrane permeabilities. A simulation study

Molecular dynamics simulations were used to study the permeation of four different solutesthrough different cholesterol containing lipid bilayers. In all bilayers the limiting permeationbarrier shifted towards the hydrophobic core, as the cholesterol concentration was increased.Cholesterols reducing...

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Bibliographic Details
Main Author: Wennberg, Christian
Format: Others
Language:English
Published: Uppsala universitet, Institutionen för cell- och molekylärbiologi 2011
Subjects:
Molecular dynamics
permeability
cholesterol
lipid bilayer
umbrella simulation
potential of mean force
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-147722
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spelling ndltd-UPSALLA1-oai-DiVA.org-uu-1477222013-01-08T13:29:29ZEnergetics of cholesterol-modulated membrane permeabilities. A simulation studyengWennberg, ChristianUppsala universitet, Institutionen för cell- och molekylärbiologi2011Molecular dynamicspermeabilitycholesterollipid bilayerumbrella simulationpotential of mean forceMolecular dynamics simulations were used to study the permeation of four different solutesthrough different cholesterol containing lipid bilayers. In all bilayers the limiting permeationbarrier shifted towards the hydrophobic core, as the cholesterol concentration was increased.Cholesterols reducing effect on the permeation rate was observed, but under certainconditions results indicating an increased permeation rate with increasing cholesterolconcentration were also obtained.   Student thesisinfo:eu-repo/semantics/masterThesistexthttp://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-147722UPTEC X ; 11 003application/pdfinfo:eu-repo/semantics/openAccess
collection NDLTD
language English
format Others
sources NDLTD
topic Molecular dynamics
permeability
cholesterol
lipid bilayer
umbrella simulation
potential of mean force
spellingShingle Molecular dynamics
permeability
cholesterol
lipid bilayer
umbrella simulation
potential of mean force
Wennberg, Christian
Energetics of cholesterol-modulated membrane permeabilities. A simulation study
description Molecular dynamics simulations were used to study the permeation of four different solutesthrough different cholesterol containing lipid bilayers. In all bilayers the limiting permeationbarrier shifted towards the hydrophobic core, as the cholesterol concentration was increased.Cholesterols reducing effect on the permeation rate was observed, but under certainconditions results indicating an increased permeation rate with increasing cholesterolconcentration were also obtained.  
author Wennberg, Christian
author_facet Wennberg, Christian
author_sort Wennberg, Christian
title Energetics of cholesterol-modulated membrane permeabilities. A simulation study
title_short Energetics of cholesterol-modulated membrane permeabilities. A simulation study
title_full Energetics of cholesterol-modulated membrane permeabilities. A simulation study
title_fullStr Energetics of cholesterol-modulated membrane permeabilities. A simulation study
title_full_unstemmed Energetics of cholesterol-modulated membrane permeabilities. A simulation study
title_sort energetics of cholesterol-modulated membrane permeabilities. a simulation study
publisher Uppsala universitet, Institutionen för cell- och molekylärbiologi
publishDate 2011
url http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-147722
work_keys_str_mv AT wennbergchristian energeticsofcholesterolmodulatedmembranepermeabilitiesasimulationstudy
_version_ 1716521951187435520

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