Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials

Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials

Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider...

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Bibliographic Details
Main Author: Karlsson, Kristin E
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för farmaceutisk biovetenskap 2010
Subjects:
model-based analysis
pharmacometrics
modeling
disease progression
NONMEM
SAEM
Importance sampling
repeated time-to-event
RTTCE
RCEpT
NIH stroke scale
Barthel index
internal validation
external validation
study power
study design
PHARMACY
FARMACI
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-133104

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-133104

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