Aβ Conformation Dependent Antibodies and Alzheimer's Disease
Soluble intermediates of the amyloid-β (Aβ) aggregation process are suggested to play a central role in the pathogenesis of Alzheimer’s disease (AD) by causing synaptic dysfunction and neuronal loss. In this thesis, soluble Aβ aggregates have been studied with...
Main Author: | Sehlin, Dag |
---|---|
Format: | Doctoral Thesis |
Language: | English |
Published: |
Uppsala universitet, Geriatrik
2010
|
Subjects: | |
Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132736 http://nbn-resolving.de/urn:isbn:978-91-554-7949-7 |
Similar Items
-
Amyloid-β Protofibrils in Alzheimer´s Disease : Focus on Antibodies, Inflammation and Astrocytes
by: Söllvander, Sofia
Published: (2015) -
Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody
by: Stina Syvänen, et al.
Published: (2018-05-01) -
Amyloid-β Protofibril Formation and Neurotoxicity : Implications for Alzheimer’s Disease
by: Johansson, Ann-Sofi
Published: (2007) -
Protofibrils of Amyloid-β are Important Targets of a Disease-Modifying Approach for Alzheimer’s Disease
by: Kenjiro Ono, et al.
Published: (2020-01-01) -
SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease
by: Tobias Gustavsson, et al.
Published: (2020-09-01)