Design and Synthesis of Angiotensin IV Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP)

Design and Synthesis of Angiotensin IV Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP)

Peptidomimetics derived from the bioactive hexapeptide angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) have been designed and synthesized. These peptidomimetics are aimed at inhibiting the insulin-regulated amino peptidase (IRAP), also known as the AT4 receptor. This membrane-bound zinc-metal...

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Bibliographic Details
Main Author: Andersson, Hanna
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Avdelningen för organisk farmaceutisk kemi 2010
Subjects:
angiotensin IV
AT4
insulin-regulated aminopeptidase (IRAP)
inhibitor
peptidomimetics
γ-turn mimetic
macrocycle
Pharmaceutical chemistry
Läkemedelskemi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122218
http://nbn-resolving.de/urn:isbn:978-91-554-7783-7

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122218
http://nbn-resolving.de/urn:isbn:978-91-554-7783-7

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