| Summary: | Masked Volume-Wise Principal Component Analysis (MVW-PCA) is used in Positron Emission Tomography (PET) to distinguish structures with different kinetic behaviours of an administered tracer. In the article where MVW-PCA was introduced, a noise pre-normalization was suggested due to temporal and spatial variations of the noise between slices. However, the noise pre-normalization proposed in that article was only applicable on datasets reconstructed using the analytical method Filtered Back-Projection (FBP). This study aimed at developing a new noise pre-normalization that is applicable on datasets regardless of whether the dataset was reconstructed with FBP or an iterative reconstruction algorithm, such as Ordered Subset Expectation Maximization (OSEM). A phantom study was performed to investigate the differences of expectation values and standard deviations of datasets reconstructed with FBP and OSEM. A novel noise pre-normalization method named "higher-order principal component noise pre-normalization" (HOPC noise pre-normalization) was suggested and evaluated against other pre-normalization methods on both synthetic and clinical datasets. Results showed that MVW-PCA of data reconstructed with FBP was much more dependent on an appropriate pre-normalization than analysis of data reconstructed with OSEM. HOPC noise pre-normalization showed an overall good performance with both FBP and OSEM reconstructions, whereas the other pre-normalization methods only performed well with one of the two methods. The HOPC noise pre-normalization has potential for improving the results from MVW-PCA on dynamic PET datasets independent of used reconstruction algorithm.
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