Design and Synthesis of Aspartic and Serine Protease Inhibitors : Targeting the BACE-1 and the HCV NS3 Protease

Design and Synthesis of Aspartic and Serine Protease Inhibitors : Targeting the BACE-1 and the HCV NS3 Protease

This thesis describes work done to design and synthesize protease inhibitors, with the intention of developing therapeutic agents for Alzheimer’s disease (AD) and the chronic liver condition caused by infection of the hepatitis C virus (HCV). AD is the most common form of dementia, and HCV infection...

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Bibliographic Details
Main Author: Wångsell, Fredrik
Format: Doctoral Thesis
Language:English
Published: Uppsala universitet, Institutionen för läkemedelskemi 2009
Subjects:
Alzheimer's disease
BACE-1
transition state mimetic
tertiary hydroxyl group
hydroxyethylene
statine
hydroxyethylamine
hepatitis C
HCV NS3
bioisostere
protease inhibitor.
Pharmaceutical chemistry
Läkemedelskemi
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108985
http://nbn-resolving.de/urn:isbn:978-91-554-7623-6

Internet

http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108985
http://nbn-resolving.de/urn:isbn:978-91-554-7623-6

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