Mechanistic Implications and Characterization of Anaplastic Lymphoma Kinase (ALK) mutations in Neuroblastoma

Mechanistic Implications and Characterization of Anaplastic Lymphoma Kinase (ALK) mutations in Neuroblastoma

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that was first reported as a fusion partner of nucleophosmin in Anaplastic large cell lymphoma in 1994. ALK is involved in myriad of cancers including neuroblastoma which is the most common extracranial solid tumor affecting young childr...

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Bibliographic Details
Main Author: Chand, Damini
Format: Doctoral Thesis
Language:English
Published: Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten) 2015
Subjects:
neuroblastoma
ALK
crizotinib
receptor tyrosine kinase
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106663
http://nbn-resolving.de/urn:isbn:978-91-7601-254-3

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