Design and Synthesis of Inhibitors Targeting BACE-1, an Aspartic Protease Involved in the Pathogenesis of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common form of dementia, occurring in an estimated 24 million people worldwide. Accumulation of amyloid-b peptides leads to development of plaques in the brain, which eventually stimulates hyperphosphorylation of tau proteins leading to tangles. This is believed...
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| Format: | Doctoral Thesis |
| Language: | English |
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Linköpings universitet, Organisk Kemi
2012
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| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76174 http://nbn-resolving.de/urn:isbn:978-91-7519-933-7 |