Synthesis of azidoethyl 3,4,6-tri-O-acetyl-α-D-mannopyranoside for future bioconjugation in PET studies
Positron emission tomography is a powerful imaging method capable of diagnosing and studyingdiseases at atomic levels. The following thesis involves the synthesis of a 2 -deoxy-2 -[18F]uoro-D-glucose derivative able to participate in click chemisty conjugation. The synthesis involves six stepswith D...
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| Format: | Others |
| Language: | English |
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Linköpings universitet, Organisk Kemi
2013
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| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-102909 |
| Summary: | Positron emission tomography is a powerful imaging method capable of diagnosing and studyingdiseases at atomic levels. The following thesis involves the synthesis of a 2 -deoxy-2 -[18F]uoro-D-glucose derivative able to participate in click chemisty conjugation. The synthesis involves six stepswith D-mannopyranose as starting material; regioselective acetylation and protection of the hydroxylgroup on C-2 of the monosaccharide, glycosylation with 2-azidoethanol, removal of the selectiveprotecting group and substitution of the hydroxyl group on C-2 with uorine. The potential toconjugate the glycoside to other biomolecules and obtain PET data might have uses in diagnosticaland medicinal chemistry. |
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