Detecting contacts in protein folds by solving the inverse Potts problem - a pseudolikelihood approach
Abstract Spatially proximate amino acid positions in a protein tend to co-evolve, so a protein's 3D-structure leaves an echo of correlations in the evolutionary record. Reverse engineering 3D-structures from such correlations is an open problem in structural biology, pursued with increasing vi...
| Main Author: | |
|---|---|
| Format: | Others |
| Language: | English |
| Published: |
KTH, Matematisk statistik
2012
|
| Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-99181 |