Frequency of CCR2V64I and CCR5Δ32 host genes and their association with HIV infection among pregnant women from Harare, Zimbabwe

Frequency of CCR2V64I and CCR5Δ32 host genes and their association with HIV infection among pregnant women from Harare, Zimbabwe

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Aim: To determine and compare the prevalence of CCR5-Δ32 and CCRV64I genes in HIV positive and HIV negative population of pregnant women from Harare, in Zimbabwe.Results: The proportion of pregnant women with the homozygous CCR2V64I gene was 24.38% and this gene was two times more associated with H...

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Bibliographic Details
Main Author: Soko, White
Format: Others
Language:English
Published: 2010
Subjects:
HIV in pregnant women
Host genetic factors
Gene polymorphism
Mutation
Protective effect
CCR5-Δ32 CCR2V64I
Vaccines
Chemotherapeutic drugs
Zimbabwe.
Online Access:http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_4983_1319103621
id ndltd-UNWC-oai-UWC_ETD-http%3A%2F%2Fetd.uwc.ac.za%2Findex.php%3Fmodule%3Detd%26action%3Dviewtitle%26id%3Dgen8Srv25Nme4_4983_1319103621
record_format oai_dc
spelling ndltd-UNWC-oai-UWC_ETD-http%3A%2F%2Fetd.uwc.ac.za%2Findex.php%3Fmodule%3Detd%26action%3Dviewtitle%26id%3Dgen8Srv25Nme4_4983_13191036212013-01-08T12:43:11Z Frequency of CCR2V64I and CCR5Δ32 host genes and their association with HIV infection among pregnant women from Harare, Zimbabwe Soko, White HIV in pregnant women Host genetic factors Gene polymorphism Mutation Protective effect CCR5-Δ32 CCR2V64I Vaccines Chemotherapeutic drugs Zimbabwe. Aim: To determine and compare the prevalence of CCR5-Δ32 and CCRV64I genes in HIV positive and HIV negative population of pregnant women from Harare, in Zimbabwe.Results: The proportion of pregnant women with the homozygous CCR2V64I gene was 24.38% and this gene was two times more associated with HIV infection than in those without it ( RR= 2.32, 95% CI-1.38-3.92). No CCR5-Δ32 deletion was detected in the studied population. Conclusion: The homozygous CCR2V64I gene and STIs were more prevalent in HIV infected pregnant women than in uninfected pregnant women and no homozygous CCR5-Δ32 gene was detected in this study. 2010 Thesis and dissertation Pdf http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_4983_1319103621 English ZA Copyright: University of the Western Cape
collection NDLTD
language English
format Others
sources NDLTD
topic HIV in pregnant women
Host genetic factors
Gene polymorphism
Mutation
Protective effect
CCR5-Δ32 CCR2V64I
Vaccines
Chemotherapeutic drugs
Zimbabwe.
spellingShingle HIV in pregnant women
Host genetic factors
Gene polymorphism
Mutation
Protective effect
CCR5-Δ32 CCR2V64I
Vaccines
Chemotherapeutic drugs
Zimbabwe.
Soko, White
Frequency of CCR2V64I and CCR5Δ32 host genes and their association with HIV infection among pregnant women from Harare, Zimbabwe
description Aim: To determine and compare the prevalence of CCR5-Δ32 and CCRV64I genes in HIV positive and HIV negative population of pregnant women from Harare, in Zimbabwe.Results: The proportion of pregnant women with the homozygous CCR2V64I gene was 24.38% and this gene was two times more associated with HIV infection than in those without it ( RR= 2.32, 95% CI-1.38-3.92). No CCR5-Δ32 deletion was detected in the studied population. Conclusion: The homozygous CCR2V64I gene and STIs were more prevalent in HIV infected pregnant women than in uninfected pregnant women and no homozygous CCR5-Δ32 gene was detected in this study.
author Soko, White
author_facet Soko, White
author_sort Soko, White
title Frequency of CCR2V64I and CCR5Δ32 host genes and their association with HIV infection among pregnant women from Harare, Zimbabwe
title_short Frequency of CCR2V64I and CCR5Δ32 host genes and their association with HIV infection among pregnant women from Harare, Zimbabwe
title_full Frequency of CCR2V64I and CCR5Δ32 host genes and their association with HIV infection among pregnant women from Harare, Zimbabwe
title_fullStr Frequency of CCR2V64I and CCR5Δ32 host genes and their association with HIV infection among pregnant women from Harare, Zimbabwe
title_full_unstemmed Frequency of CCR2V64I and CCR5Δ32 host genes and their association with HIV infection among pregnant women from Harare, Zimbabwe
title_sort frequency of ccr2v64i and ccr5î”32 host genes and their association with hiv infection among pregnant women from harare, zimbabwe
publishDate 2010
url http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_4983_1319103621
work_keys_str_mv AT sokowhite frequencyofccr2v64iandccr5i32hostgenesandtheirassociationwithhivinfectionamongpregnantwomenfromhararezimbabwe
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