Cd4 silencing in thymocytes is opposed by the enforced association of p300 hat, hdac1 or suv39h1 with runx transcription factors
The transcription factors Runx1 and Runx3 are required for permanent silencing of CD4 in maturing CD8+ thymocytes. Runx binding to consensus sites within the CD4 silencer region is required for CD4 silencing post-positive selection. The Runx nuclear matrix targeting sequence (NMTS) is required for C...
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| Language: | ENG |
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ScholarWorks@UMass Amherst
2013
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| Online Access: | https://scholarworks.umass.edu/dissertations/AAI3615422 |