Runx1 regulates c-Myc expression and the expansion of hematopoietic precursors in a C-terminally dependent manner
Runx1 regulates the expression of several important target genes and plays critical roles in the process of hematopoiesis. Runx1 by itself is a poor regulator of transcription and instead nucleates transcription complexes through its C-terminus to transactivate or repress the expression of target ge...
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| Language: | ENG |
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ScholarWorks@UMass Amherst
2012
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| Online Access: | https://scholarworks.umass.edu/dissertations/AAI3518245 |