Regulation of the inositol 1,4,5-trisphosphate receptor degradation during fertilization and its impact on [calcium(2+)](i) signaling in mammalian eggs
Fertilization initiates a series of intracellular calcium [Ca 2+]i oscillations in the oocyte that promote its exit from and completion of meiosis. In mouse oocytes, the [Ca2+] i oscillations arrest at the pronuclear stage and this is accompanied by a down-regulation in the inositol 1,4,5-trisphosph...
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| Language: | ENG |
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ScholarWorks@UMass Amherst
2002
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| Online Access: | https://scholarworks.umass.edu/dissertations/AAI3068567 |