Mechanism-based inhibitors as in vitro and in vivo probes of glycosidase structure and mechanism

Two new classes of specific, mechanism-based glycosidase inactivators were developed: 2,2-dihalo glycosyl chlorides and 5-fluoro glycosyl fluorides. Both classes were effective against x-glucosidases, which had been hitherto resistant to similar inactivation strategies. Incubation of yeast -gluco...

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Bibliographic Details
Main Author: McCarter, John D.
Format: Others
Language:English
Published: 2009
Online Access:http://hdl.handle.net/2429/7515

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