Structural characterization of superbug proteins involved in regulating beta-lactam resistance

Structural characterization of superbug proteins involved in regulating beta-lactam resistance

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The widespread use of β-lactams has undermined their effectiveness as chemotherapeutic agents by fueling the evolution and dissemination of multiple resistance mechanisms, including: (1) production of hydrolytic β-lactamase enzymes that inactivate β-lactams, (2) expression of PBPs with low-affinity...

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Bibliographic Details
Main Author:	Wilke, Mark Steven
Format:	Others
Language:	English
Published:	University of British Columbia 2008
Subjects:	Biochemistry Structural biology Superbug Beta-lactam Antibiotic resistance Crystallography Staphylococcus aureus Pseudomonas aeruginosa
Online Access:	http://hdl.handle.net/2429/725

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