Quantifying and modeling the melting thermodynamics of chemically modified duplex DNA
Biological reagents that bind a target selectively and with high affinity are widely used as recognition molecules within diagnostic assays and as therapeutics, among other applications. By leveraging their Watson-Crick base pairing ability, short DNA oligonucelotides represent one class of such bio...
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| Language: | English |
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University of British Columbia
2016
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| Online Access: | http://hdl.handle.net/2429/58855 |