Synthesis of autophagy inhibiting virantmycin analogs
(–)-Virantmycin (1.12), first isolated from Streptomyces nitrosporeus in 1981, was found to be a potent inhibitor of autophagy with an IC₅₀ of 0.5 μM against rapamycin-induced autophagy in MCF-7 cells. Recent studies showed that autophagy inhibition considerably reduced the growth of pancreatic duct...
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| Language: | English |
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University of British Columbia
2015
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| Online Access: | http://hdl.handle.net/2429/54843 |